(19)

(11)

EP 1 187 836 A1

(12)

(43) Date of publication: 20.03.2002 Bulletin 2002/12 (21) Application number: 00927197.4 (22) Date of filing: 11.05.2000

(51) International Patent Classification (IPC)7: C07D 513/04, A61K 31/425 (86) International application number: PCT/EP0004/278 (87) International publication number: WO 0071/548 (30.11.2000 Gazette 2000/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.05.1999 GB 9911881 (71) Applicant: Knoll GmbH 67061 Ludwigshafen (DE)	(72) Inventors: BROUGH, Paul, Andrew Nottingham NG1 1GF (GB) HENSTOCK, Vincent Nottingham NG1 1GF (GB) WATTS, John, Paul Nottingham NG1 1GF (GB) (74) Representative: Nash, David Allan  Haseltine Lake & Co.,Imperial House,15-19 Kingsway London WC2B 6UD London WC2B 6UD (GB)