(19)

(11)

EP 1 189 576 A2

(12)

(88) Date of publication A3: 05.07.2001 (43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00940802.2 (22) Date of filing: 22.06.2000

(51) International Patent Classification (IPC)7: A61K 7/00 (86) International application number: PCT/JP0004/090 (87) International publication number: WO 0100/144 (04.01.2001 Gazette 2001/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.06.1999 JP 18696199 (71) Applicant: Lion Corporation Tokyo 130-8644 (JP)	(72) Inventors: MITAMURA, Joji Tokyo 130-8644 (JP) ONUKI, Takeshi Tokyo 130-8644 (JP) NOGUCHI, Mutsumi Tokyo 130-8644 (JP) (74) Representative: Stuart, Ian Alexander et al MEWBURN ELLISYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)