(19)

(11)

EP 1 189 633 A2

(12)

(88) Date of publication A3: 05.07.2001 (43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00944821.8 (22) Date of filing: 22.06.2000

(51) International Patent Classification (IPC)7: A61K 39/29, A61P 31/20 // (A61K39/29, 31:505) (86) International application number: PCT/US0017/298 (87) International publication number: WO 0078/343 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.06.1999 US 140508 P (71) Applicant: CHIRON CORPORATION Emeryville,California 94608 (US)	(72) Inventor: HSU, Henry Hillsborough, CA 94010 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)