(19)

(11)

EP 1 189 944 A1

(12)

(43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00942952.3 (22) Date of filing: 19.06.2000

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 16/28, C12N 15/12 (86) International application number: PCT/US0016/869 (87) International publication number: WO 0078/809 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.06.1999 US 337105 (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: ELSHOURBAGY, Nabil West Chester, PA 19380 (US) SHABON, Usman Collegeville, PA 19426 (US) (74) Representative: Connell, Anthony Christopher  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)