(19)

(11)

EP 1 190 054 A1

(12)

(43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00946824.0 (22) Date of filing: 19.06.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, G01N 33/574, C12Q 1/68, A61K 38/17 (86) International application number: PCT/US0016/900 (87) International publication number: WO 0078/955 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.06.1999 US 139995 P (71) Applicant: Biotherapies, Inc. Ann Arbor, MI 48018 (US)	(72) Inventor: ERVIN, Paul, R., Jr. Ann Arbor, MI 48105 (US) (74) Representative: Prins, Adrianus Willem et al Vereenigde,Nieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)