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(11)

EP 1 190 061 A1

(12)

(43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00941246.1 (22) Date of filing: 05.06.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C12N 15/13, C12N 15/62, C12N 15/72, C12N 1/21, C07K 14/36, C07K 16/28, A61K 39/395, A61K 47/48 (86) International application number: PCT/US0015/595 (87) International publication number: WO 0075/333 (14.12.2000 Gazette 2000/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.06.1999 US 137900 P 03.12.1999 US 168976 P (71) Applicant: NEORX CORPORATION SeattleWashington 98119 (US)

(72) Inventors: GOSHORN, Stephen, Charles Shoreline, WA 98177 (US) GRAVES, Scott, Stoll Monroe, WA 98272 (US) SCHULTZ, Joanne, Elaine Seattle, WA 98112 (US) LIN, Yukang Kenmore, WA 98028 (US) SANDERSON, James, Allen Seattle, WA 98125 (US) RENO, John, M. Brier, WA 98036 (US) (74) Representative: Gowshall, Jonathan Vallance  FORRESTER & BOEHMERTPettenkoferstrasse 20-22 80336 München 80336 München (DE)