(19)

(11)

EP 1 190 083 A2

(12)

(88) Date of publication A3: 15.11.2001 (43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00942269.2 (22) Date of filing: 05.07.2000

(51) International Patent Classification (IPC)7: C12N 15/85, C12N 15/12, C12N 5/10, A61K 31/17 (86) International application number: PCT/GB0002/569 (87) International publication number: WO 0102/594 (11.01.2001 Gazette 2001/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.07.1999 GB 9915638 14.12.1999 GB 9929547 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)

(72) Inventors: GREAVES, David RobertSir William Dunn Sch. Path. OxfordOxfordshire OX1 3RE (GB) THOMSEN, Lindy Stevenage, Hertfordshire SG1 2NY (GB) CATCHPOLE, Ian Richard StevenageHertfordshire SN1 2NY (GB) FORD, Martin James StevenageHertfordshire SN1 2NY (GB) (74) Representative: Dalton, Marcus Jonathan William et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford,Middlesex TW8 9GS Brentford,Middlesex TW8 9GS (GB)