(19)

(11)

EP 1 190 089 A2

(12)

(88) Date of publication A3: 24.01.2002 (43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00946845.5 (22) Date of filing: 22.06.2000

(51) International Patent Classification (IPC)7: C12P 21/06, C12P 21/04, C12N 1/20, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74, C12N 5/00, C12N 5/02, C07K 1/00, C07K 14/00, C07K 17/00 (86) International application number: PCT/US0017/251 (87) International publication number: WO 0100/787 (04.01.2001 Gazette 2001/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.06.1999 US 141156 P (71) Applicants: SmithKline Beecham Corporation Philadelphia, PA 19103 (US) SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)

(72) Inventors: BINGHAM, Sharon Harlow,Essex CM19 5AW (GB) DARKER, John Harlow,Essex CM19 5AW (GB) LIU, Wu-Schyong King of Prussia, PA 19406 (US) MARTIN, John, D. Glocester City, NJ 08030 (US) PARSONS, Andrew, A. Berwyn, PA 19312 (GB) PATEL, Saraswati, R. Essex CM16 5EN (GB) (74) Representative: Hockley, Siân Catherine  GlaxoSmithKline,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)