(19)

(11)

EP 1 190 343 A2

(12)

(88) Date of publication A3: 30.11.2000 (43) Date of publication: 27.03.2002 Bulletin 2002/13 (21) Application number: 00919318.6 (22) Date of filing: 18.02.2000

(51) International Patent Classification (IPC)7: G06F 17/10, G06F 17/27, G06F 15/00 (86) International application number: PCT/US0004/118 (87) International publication number: WO 0049/517 (24.08.2000 Gazette 2000/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.02.1999 US 120659 P (71) Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK New York,New York 10027 (US)	(72) Inventors: MCKEOWN, Kathleen, R. Wayne, NJ 07470 (US) BARZILAY, Regina New York, NY 10027 (US) (74) Representative: Lucas, Brian Ronald  Lucas & Co.135 Westhall Road WarlinghamSurrey CR6 9HJ WarlinghamSurrey CR6 9HJ (GB)