(19)
(11) EP 1 192 143 A1

(12)

(43) Date of publication:
03.04.2002 Bulletin 2002/14

(21) Application number: 00938021.3

(22) Date of filing: 31.05.2000
(51) International Patent Classification (IPC)7C07D 277/20, C07D 277/36, C07D 417/06, A61K 31/426, A61K 31/427, A61P 25/28
(86) International application number:
PCT/US0015/069
(87) International publication number:
WO 0076/987 (21.12.2000 Gazette 2000/51)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 10.06.1999 US 138544 P

(71) Applicants:
  • WARNER-LAMBERT COMPANY
    Morris PlainsNew Jersey 07950 (US)
  • Yamanouchi Pharmaceutical Company
    Tokyo 174-8612 (JP)

(72) Inventors:
  • AUGELLI-SZAFRAN, Corinne, Elizabeth
    Ann Arbor, MI 48103 (US)
  • GLASE, Shelly, Ann
    Ann Arbor, MI 48105 (US)
  • WALKER, Lary, Craswell
    Ann Arbor, MI 48105 (US)
  • YASUNAGA, Tomoyuki
    Ushiku,Ibaraki 300-1222 (JP)

(74) Representative: Tesch, Rudolf, Dr. 
c/o Gödecke GmbH,Patentwesen,Mooswaldallee 1
79090 Freiburg
79090 Freiburg (DE)

   


(54) RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS