(19)

(11)

EP 1 192 146 A1

(12)

(43) Date of publication: 03.04.2002 Bulletin 2002/14 (21) Application number: 00938917.2 (22) Date of filing: 14.06.2000

(51) International Patent Classification (IPC)7: C07D 311/68, C07D 405/12, A61K 31/353, A61P 25/00 (86) International application number: PCT/GB0002/304 (87) International publication number: WO 0078/742 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.06.1999 GB 9914025 (71) Applicant: AstraZeneca UK Limited London W1Y 6LN (GB)	(72) Inventors: CHEN, Deborah, Weng, Chun Wilmington, DE 19850-5437 (US) FORST, Janet, Marie Wilmington, DE 19850-5437 (US) (74) Representative: Wahlström, Stig Christer Gunnar  Astra ABIntellectual Property, Patents S-151 85 Södertälje S-151 85 Södertälje (SE)