(19)

(11)

EP 1 192 243 A1

(12)

(43) Date of publication: 03.04.2002 Bulletin 2002/14 (21) Application number: 00943131.3 (22) Date of filing: 22.06.2000

(51) International Patent Classification (IPC)7: C12N 5/00, A01N 63/00 (86) International application number: PCT/US0017/427 (87) International publication number: WO 0078/930 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.06.1999 US 140628 P (71) Applicant: Oregon Health and Science University Portland, OR 97201-3098 (US)	(72) Inventor: FLEMING, William, H. Portland, OR 97201 (US) (74) Representative: Gowshall, Jonathan Vallance  FORRESTER & BOEHMERTPettenkoferstrasse 20-22 80336 München 80336 München (DE)