(19)

(11)

EP 1 192 252 A2

(12)

(88) Date of publication A3: 19.04.2001 (43) Date of publication: 03.04.2002 Bulletin 2002/14 (21) Application number: 00944929.9 (22) Date of filing: 28.06.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 19/00, C07K 16/18, C07K 16/42, C12N 15/62, C12N 15/63 (86) International application number: PCT/US0017/692 (87) International publication number: WO 0102/565 (11.01.2001 Gazette 2001/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.07.1999 US 346502 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: HOLLOWAY, James, L. Seattle, WA 98115 (US) LOK, Si Seattle, WA 98107 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)