(19)
(11) EP 1 193 256 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION

(48) Corrigendum issued on:
28.08.2002 Bulletin 2002/35

(43) Date of publication:
03.04.2002 Bulletin 2002/14

(21) Application number: 00810888.8

(22) Date of filing: 27.09.2000
(51) International Patent Classification (IPC)7: C07D 211/96, A61K 31/4468, A61P 25/00, A61P 37/00
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(71) Applicant: Applied Research Systems ARS Holding N.V.
Curacao (AN)

(72) Inventors:
  • Halazy, Serge
    74100 Vetraz-Monthoux (FR)
  • Church, Dennis
    1291 Commugny (CH)
  • Camps, Montserrat
    1290 Versoix (CH)
  • Rueckle, Thomas
    1228 Plan-Les-Ouates (CH)
  • Gotteland, Jean Pierre
    74160 Beaumont (FR)
  • Biamonte, Marco
    1227 Carouge (CH)
  • Arkinstall, Stephen
    Belmont, MA 02478 (US)

(74) Representative: Moinas, Michel et al
MOINAS SAVOYE & CRONIN, 42 rue Plantamour
1201 Genève
1201 Genève (CH)

   


(54) Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins


(57) The present invention is related to benzsulfonamide derivatives of formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzsulfonamide derivatives. Said benzsulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel benzsulfonamide derivatives as well as to methods of their preparation.
The compounds of formula I according to the present invention being suitable pharmaceutical agents are those wherein
  • Ar1 is a substituted or unsubstituted aryl or heteroaryl group;
  • Ar2 is a substituted or unsubstituted phenyl group;
  • X is O or S, preferably O;
  • R1 is hydrogen or a C1-C6-alkyl group, or R1 forms a substituted or unsubstituted 5-6-membered saturated or unsaturated ring with Ar1;
  • n is an integer from 0 to 5, preferably between 1-3 and most preferred 1;
  • Y within formula I is an unsubstituted or a substituted 4-12-membered saturated cyclic or bicyclic alkyl containing at least one nitrogen atom, whereby one nitrogen atom within said ring is forming a bond with the sulfonyl group of formula I thus providing a benzsulfonamide.