(19)

(11)

EP 1 194 143 A2

(12)

(88) Date of publication A3: 17.05.2001 (43) Date of publication: 10.04.2002 Bulletin 2002/15 (21) Application number: 00946813.3 (22) Date of filing: 15.06.2000

(51) International Patent Classification (IPC)7: A61K 31/33, A61K 31/17 (86) International application number: PCT/US0016/500 (87) International publication number: WO 0076/457 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.06.1999 US 139680 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: BENSON, Gregory, Martin Essex CM19 5AW (GB) WIDDOWSON, Katherine, L. King of Prussia, PA 19406 (US) (74) Representative: Blakey, Alison Jane et al GlaxoSmithKlineCorporate Intellectual PropertyTwo New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)