(19)

(11)

EP 1 194 187 A1

(12)

(43) Date of publication: 10.04.2002 Bulletin 2002/15 (21) Application number: 00939927.0 (22) Date of filing: 16.06.2000

(51) International Patent Classification (IPC)7: A61P 31/04, A61K 39/40 (86) International application number: PCT/US0016/581 (87) International publication number: WO 0076/587 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.06.1999 US 139524 P (71) Applicants: Aventis Pasteur Swiftwater, PA 18370-00187 (US) UAB Research Foundation Birmingham,Alabama 35294-0111 (US)	(72) Inventors: NABORS, Gary, S. Stroudsburg, PA 18360 (US) BRILES, David Birmingham, AL 35222 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)