(19)

(11)

EP 1 194 549 A2

(12)

(88) Date of publication A3: 30.08.2001 (43) Date of publication: 10.04.2002 Bulletin 2002/15 (21) Application number: 00947021.2 (22) Date of filing: 30.06.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/55, C12N 15/54, C12N 15/61, C07K 14/47, C12N 9/64, C12N 9/12, C12N 9/90, C12Q 1/68, C12N 15/11, C07K 16/18, C07K 16/40, G01N 33/566, A61K 38/00 (86) International application number: PCT/US0018/374 (87) International publication number: WO 0102/568 (11.01.2001 Gazette 2001/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.07.1999 US 142310 P 02.07.1999 US 142311 P (71) Applicants: CHIRON CORPORATION Emeryville,California 94608 (US) HYSEQ, INC. Sunnyville, CA 94086 (US)

(72) Inventors: Williams, Lewis T. Emeryville, CA 94662-8097 (US) Escobedo, Jaime Emeryville, CA 94662-8097 (US) Innis, Michael A. Emeryville, CA 94662-8097 (US) Garcia, Pablo Dominguez Emeryville, CA 94662-8097 (US) Klinger, Julie Emeryville, CA 94662-8097 (US) Kassam, Altaf Emeryville, CA 94662-8097 (US) Reinhard, Christoph Emeryville, CA 94662-8097 (US) Randazzo, Filippo Emeryville, CA 94662-8097 (US) Kennedy, Guilia C. Emeryville, CA 94662-8097 (US) Pot, David Emeryville, CA 94662-8097 (US) Lamson, George Emeryville, CA 94662-8097 (US) Drmanac, Radoje Sunnyvale, CA 94086 (US) Crkenjakov, Radomir Sunnyvale, CA 94086 (US) Drmanac, Snezana Sunnyvale, CA 94086 (US) Dickson, Mark Sunnyvale, CA 94086 (US) Labat, Ivan Sunnyvale, CA 94086 (US) Leshkowitiz, Dena Sunnyvale, CA 94086 (US) Kita, David Sunnyvale, CA 94086 (US) Garcia, Veronica Sunnyvale, CA 94086 (US) Strache-Crain, Birgit Sunnyvale, CA 94086 (US) (74) Representative: Irvine, Jonquil Claire  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)