(19)

(11)

EP 1 194 553 A1

(12)

(43) Date of publication: 10.04.2002 Bulletin 2002/15 (21) Application number: 00956163.0 (22) Date of filing: 04.07.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 5/10, C07K 14/47, C07K 16/18, G01N 33/50 (86) International application number: PCT/EP0006/254 (87) International publication number: WO 0104/293 (18.01.2001 Gazette 2001/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.07.1999 GB 9916195 (71) Applicant: Smithkline Beecham PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: Herdon, Hugh Jonathan,SmithKline Beecham Pharm., Harlow,Essex CM19 5AW (GB) Evans, Joanne, RachelSmithKline Beecham Pharma., Harlow, Essex CM19 5AW (GB) (74) Representative: Connell, Anthony Christopher  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)