(19)

(11)

EP 1 194 571 A1

(12)

(43) Date of publication: 10.04.2002 Bulletin 2002/15 (21) Application number: 00947977.5 (22) Date of filing: 11.07.2000

(51) International Patent Classification (IPC)7: C12N 15/62, C07K 19/00, C12N 1/21, A61K 39/00, A61K 31/70 // C12N9/64, C07K14/11 (86) International application number: PCT/EP0006/618 (87) International publication number: WO 0104/143 (18.01.2001 Gazette 2001/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.07.1999 US 352616 12.11.1999 US 439313 18.11.1999 US 443686 14.01.2000 US 483672 27.03.2000 US 536857 09.05.2000 US 568100 12.05.2000 US 570737 13.06.2000 US 593793 27.06.2000 GB 0015747 27.06.2000 US 605783 (71) Applicants: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE) CORIXA CORPORATION Seattle, WA 98104 (US)

(72) Inventors: CABEZON SILVA, Teresa B-1330 Rixensart (BE) DILLON, Davin Clifford Seattle, WA 98104 (US) (74) Representative: Dalton, Marcus Jonathan William  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford,Middlesex TW8 9GS Brentford,Middlesex TW8 9GS (GB)