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(11)

EP 1 194 576 A1

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(43) Date of publication: 10.04.2002 Bulletin 2002/15 (21) Application number: 00942323.7 (22) Date of filing: 23.06.2000

(51) International Patent Classification (IPC)7: C12N 15/74, C12N 15/90, C12N 1/21, A61K 39/106 // C12R1:63 (86) International application number: PCT/IB0000/974 (87) International publication number: WO 0100/857 (04.01.2001 Gazette 2001/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.06.1999 GB 9914960 (71) Applicant: Chiron S.p.A. 53100 Siena (IT)	(72) Inventor: PIZZA, Mariagrazia I-53100 Siena (IT) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)