(19)

(11)

EP 1 196 437 A1

(12)

(43) Date of publication: 17.04.2002 Bulletin 2002/16 (21) Application number: 00947385.1 (22) Date of filing: 14.07.2000

(51) International Patent Classification (IPC)7: C07K 14/245, C12N 15/31, A61K 39/00, C07K 16/12 (86) International application number: PCT/US0019/277 (87) International publication number: WO 0105/827 (25.01.2001 Gazette 2001/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.07.1999 US 144013 P (71) Applicants: MEDIMMUNE, INC. Gaithersburg, MD 20878 (US) WASHINGTON UNIVERSITY St. Louis, MO 63110 (US)	(72) Inventors: HULTGREN, Scott, J. Ballwin, MO 63021 (US) LANGERMANN, Solomon Baltimore, MD 21215 (US) (74) Representative: LOUIS, PÖHLAU, LOHRENTZ & SEGETH  Postfach 3055 90014 Nürnberg 90014 Nürnberg (DE)