(19)
(11) EP 1 196 552 A2

(12)

(88) Date of publication A3:
02.08.2001

(43) Date of publication:
17.04.2002 Bulletin 2002/16

(21) Application number: 00944760.8

(22) Date of filing: 20.06.2000
(51) International Patent Classification (IPC)7: C12N 15/00, C12N 7/04, A61K 39/00, C12N 1/36
(86) International application number:
PCT/US0016/984
(87) International publication number:
WO 0100/234 (04.01.2001 Gazette 2001/01)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 25.06.1999 US 344655

(71) Applicant: Maxygen, Inc.
Redwood City, CA 94063 (US)

(72) Inventors:
  • PUNNONEN, Juha
    Palo Alto, CA 94306 (US)
  • HOWARD, Russell
    Los Altos Hills, CA 94022 (US)
  • STEMMER, Willem, P., C.
    Los Gatos, CA 95032 (US)
  • DELCARDAYRE, Stephen
    Belmont, CA 94002 (US)
  • APT, Doris
    Sunnyvale, CA 94068 (US)

(74) Representative: Kjerrumgaard, Lars Bo et al
Maxygen ApS,Patent Department,Agern Alle 1
2970 Horsholm
2970 Horsholm (DK)

   


(54) METHODS AND COMPOSITIONS FOR ENGINEERING OF ATTENUATED VACCINES