(19)

(11)

EP 1 196 584 A1

(12)

(43) Date of publication: 17.04.2002 Bulletin 2002/16 (21) Application number: 00940598.6 (22) Date of filing: 23.06.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/33, A61K 39/08 (86) International application number: PCT/GB0002/428 (87) International publication number: WO 0100/839 (04.01.2001 Gazette 2001/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.06.1999 GB 9914861 (71) Applicant: IMPERIAL COLLEGE OF SCIENCE,TECHNOLOGY & MEDICINE London SW7 2AZ (GB)	(72) Inventors: FAIRWEATHER, Neil Fraser Bexley, Kent DA3 3DH (GB) SINHA, Katharine,Imperial College London SW7 2AY (GB) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)