(19)

(11)

EP 1 196 632 A2

(12)

(88) Date of publication A3: 31.01.2002 (43) Date of publication: 17.04.2002 Bulletin 2002/16 (21) Application number: 00930427.0 (22) Date of filing: 05.05.2000

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US0012/391 (87) International publication number: WO 0068/434 (16.11.2000 Gazette 2000/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.05.1999 US 132969 P (71) Applicant: YALE UNIVERSITY New Haven, CT 06511 (US)	(72) Inventors: LIZARDI, Paul, M. Wallingford, CT 06492 (US) LATIMER, Darin, R. East Haven, CT 06513 (US) (74) Representative: Leissler-Gerstl, Gabriele  Eisenführ, Speiser & Partner,Patentanwälte,Arnulfstrasse 25 80335 München 80335 München (DE)