(19)

(11)

EP 1 198 243 A2

(12)

(88) Date of publication A3: 05.07.2001 (43) Date of publication: 24.04.2002 Bulletin 2002/17 (21) Application number: 00945810.0 (22) Date of filing: 23.06.2000

(51) International Patent Classification (IPC)7: A61K 39/00 (86) International application number: PCT/EP0005/841 (87) International publication number: WO 0100/231 (04.01.2001 Gazette 2001/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.06.1999 GB 9915204 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE)	(72) Inventors: COHEN, Joseph 1330 Rixensart (BE) GARCON, Nathalie 1330 Rixensart (BE) VOSS, Gerald 1330 Rixensart (BE) (74) Representative: Tyrrell, Arthur William Russell, Dr.  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)