(19)
(11) EP 1 198 250 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.11.2007 Bulletin 2007/47

(45) Mention of the grant of the patent:
26.09.2007 Bulletin 2007/39

(21) Application number: 00950483.8

(22) Date of filing: 21.07.2000
(51) International Patent Classification (IPC): 
A61K 39/39(2006.01)
A61K 39/21(2006.01)
 A61K 39/385(2006.01)
A61K 39/00(2006.01)
(86) International application number:
PCT/US2000/019816
(87) International publication number:
WO 2001/007081 (01.02.2001 Gazette 2001/05)

(54)

FC FUSION PROTEINS FOR ENHANCING THE IMMUNOGENICITY OF PROTEIN AND PEPTIDE ANTIGENS

FC-FUSIONSPROTEINE ZUR ERHÖHUNG DER IMMUNOGENITÄT VON PROTEIN- UND PEPTID-ANTIGENEN

UTILISATION DE PROTEINES HYBRIDES FC POUR AMELIORER L'IMMUNOGENEICITE D'ANTIGENES PROTEIQUE ET PEPTIDIQUE

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
LT LV RO SI

(30) Priority: 21.07.1999 US 144965 P

(43) Date of publication of application:
24.04.2002 Bulletin 2002/17

(73) Proprietor: EMD Lexigen Research Center Corp.
Billerica, MA 01821-3936 (US)

(72) Inventors:
  • GILLIES, Stephen, D.
    Carlisle, MA 01741 (US)
  • LO, Kin, Ming
    Lexington, MA 02420 (US)
  • WESOLOWSKI, John, S., Jr.
    Weymouth, MA 02189 (US)

(74) Representative: Benz, Jürgen 
Merck Patent GmbH Postfach
64271 Darmstadt
64271 Darmstadt (DE)


(56) References cited: : 
WO-A-96/08570
WO-A-98/30706
 WO-A-97/24137
US-A- 5 349 053
   
  • LO K-M ET AL: "High level expression and secretion of Fc-X fusion proteins in mammalian cells" PROTEIN ENGINEERING,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 11, no. 6, June 1998 (1998-06), pages 495-500, XP002125745 ISSN: 0269-2139
  • GUYRE P M ET AL: "Increased potency of Fc -receptor-targeted antigens." CANCER IMMUNOLOGY, IMMUNOTHERAPY, (1997 NOV-DEC) 45 (3-4) 146-8. REF: 13 , XP002924651
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).