(19)

(11)

EP 1 198 463 A2

(12)

(88) Date of publication A3: 08.03.2001 (43) Date of publication: 24.04.2002 Bulletin 2002/17 (21) Application number: 00942181.9 (22) Date of filing: 14.06.2000

(51) International Patent Classification (IPC)7: C07D 405/12, C07D 211/58, C07D 409/12, A61K 31/4468, A61K 31/453, A61K 31/4535, A61P 25/28 (86) International application number: PCT/GB0002/315 (87) International publication number: WO 0078/751 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.06.1999 GB 9914022 (71) Applicant: AstraZeneca UK Limited London W1Y 6LN (GB)	(72) Inventors: WARAWA, Edward, John Wilmington, DE 19850-5437 (US) MCLAREN, Charles, David Wilmington, DE 19850-5437 (US) SIMON-BIERENBAUM, Richard, Elliot Wilmington, DE 19850-5437 (US) (74) Representative: Wahlström, Stig Christer Gunnar  Astra ABIntellectual Property, Patents S-151 85 Södertälje S-151 85 Södertälje (SE)