(19)

(11)

EP 1 198 582 A1

(12)

(43) Date of publication: 24.04.2002 Bulletin 2002/17 (21) Application number: 00949803.1 (22) Date of filing: 07.08.2000

(51) International Patent Classification (IPC)7: C12N 15/88 (86) International application number: PCT/GB0003/040 (87) International publication number: WO 0111/069 (15.02.2001 Gazette 2001/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.08.1999 GB 9918670 (71) Applicant: Celltech R&D Limited Slough,Berkshire SL1 4EN (GB)	(72) Inventor: CROOK, Kenneth Windsor SL4 5EP (GB) (74) Representative: Golding, Louise Ann  Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)