(19)

(11)

EP 1 200 078 A1

(12)

(43) Date of publication: 02.05.2002 Bulletin 2002/18 (21) Application number: 00947081.6 (22) Date of filing: 07.07.2000

(51) International Patent Classification (IPC)7: A61K 31/21 (86) International application number: PCT/US0018/539 (87) International publication number: WO 0103/692 (18.01.2001 Gazette 2001/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.07.1999 US 143180 P (71) Applicant: Oregon Health & Science University Portland, OR 97201-3098 (US)	(72) Inventor: GOLD, Bruce, G. West Linn, OR 97068 (US) (74) Representative: Gowshall, Jonathan Vallance et al FORRESTER & BOEHMERT,Pettenkoferstrasse 20-22 80336 München 80336 München (DE)