(19)

(11)

EP 1 200 565 A2

(12)

(88) Date of publication A3: 23.08.2001 (43) Date of publication: 02.05.2002 Bulletin 2002/18 (21) Application number: 00953850.5 (22) Date of filing: 04.08.2000

(51) International Patent Classification (IPC)7: C12N 9/12, C30B 29/58, G06F 17/50, G01N 23/20 (86) International application number: PCT/US0021/425 (87) International publication number: WO 0111/025 (15.02.2001 Gazette 2001/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.08.1999 US 147117 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventor: BENSON, Timothy, E. Kalamazoo, MI 49006 (US) (74) Representative: Samuels, Lucy Alice  Gill Jennings & EveryBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)