(19)
(11) EP 1 200 589 A1

(12)

(43) Date of publication:
02.05.2002 Bulletin 2002/18

(21) Application number: 00950767.4

(22) Date of filing: 27.07.2000
(51) International Patent Classification (IPC)7C12N 15/12, C07K 14/475, A61K 38/18
(86) International application number:
PCT/US0020/432
(87) International publication number:
WO 0112/810 (22.02.2001 Gazette 2001/08)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 13.08.1999 US 373834
03.12.1999 US 454380

(71) Applicant: REGENERON PHARMACEUTICALS, INC.
Tarrytown, NY 10591-6707 (US)

(72) Inventors:
  • WIEGAND, Stanley, J.
    Ossining, NY 10562 (US)
  • SLEEMAN, Mark, W.
    Mahopac, NY 10541 (US)
  • LAMBERT, Philip, D.
    Mohegan Lake, NY 10547 (US)

(74) Representative: Duckworth, Timothy John 
J.A. Kemp & Co.,14 South Square,Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) MODIFIED CILIARY NEUROTROPHIC FACTOR, METHOD OF MAKING AND METHODS OF USE THEREOF