(19)

(11)

EP 1 200 623 A2

(12)

(88) Date of publication A3: 25.05.2001 (43) Date of publication: 02.05.2002 Bulletin 2002/18 (21) Application number: 00946122.9 (22) Date of filing: 17.07.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, C07K 14/47, C12N 15/11 (86) International application number: PCT/GB0002/741 (87) International publication number: WO 0106/005 (25.01.2001 Gazette 2001/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.07.1999 GB 9916669 05.11.1999 GB 9926293 (71) Applicant: The University of Bristol Clifton,Bristol BS8 1TH (GB)	(72) Inventors: MALIK, Karim Bristol BS8 1TD (GB) BROWN, Keith Bristol BS8 1TD (GB) (74) Representative: Tombling, Adrian George et al Withers & RogersGoldings House2 Hays Lane London SE1 2HW London SE1 2HW (GB)