(19)

(11)

EP 1 200 822 A1

(12)

(43) Date of publication: 02.05.2002 Bulletin 2002/18 (21) Application number: 00948099.7 (22) Date of filing: 11.07.2000

(51) International Patent Classification (IPC)7: G01N 33/50, G01N 33/74, C07K 14/72, C12N 5/00 (86) International application number: PCT/GB0002/674 (87) International publication number: WO 0122/082 (29.03.2001 Gazette 2001/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.07.1999 GB 9916400 (71) Applicants: UNIVERSITY COLLEGE LONDON London WC1E 7HN (GB) The University of Newcastle Jesmond,Newcastle Upon Tyne NE1 7RU (GB)	(72) Inventors: Yeaman, SteveSchool of Biochemistry and Genetics Newcastle-Upon-Tyne NE2 4HH (GB) Shepherd, PeterUniversity College London London WC1E 6BT (GB) Zorzano, AntonioUniversitat de Borcelona 08028 Barcelona (ES) (74) Representative: Harding, Charles Thomas et al D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)