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EP 1 202 731 A2

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(88) Date of publication A3: 17.05.2001 (43) Date of publication: 08.05.2002 Bulletin 2002/19 (21) Application number: 00947013.9 (22) Date of filing: 05.07.2000

(51) International Patent Classification (IPC)7: A61K 31/404, A61K 31/4192, A61K 31/4245, A61K 31/433, A61K 31/42, A61K 31/428, A61K 31/498, A61P 25/04 (86) International application number: PCT/US0018/345 (87) International publication number: WO 0105/390 (25.01.2001 Gazette 2001/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.07.1999 US 144418 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)

(72) Inventors: BARRETT, Stephen, Douglas Livonia, MI 48154 (US) BRIDGES, Alexander, James Saline, MI 48176 (US) TECLE, Haile Ann Arbor, MI 48108 (US) DIXON, Alistair Cambridge CB1 2LL (GB) LEE, Kevin Cambridge CB1 9YT (GB) PINNOCK, Robert, Denham Cambridge CB1 9YT (GB) (74) Representative: Tesch, Rudolf, Dr. et al Warner-Lambert Company,Legal Division,Patent Department,c/o Gödecke AG,Mooswaldallee 1 79090 Freiburg 79090 Freiburg (DE)