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(11)

EP 1 204 411 A1

(12)

(43) Date of publication: 15.05.2002 Bulletin 2002/20 (21) Application number: 00947507.0 (22) Date of filing: 19.07.2000

(51) International Patent Classification (IPC)7: A61K 31/395, A61K 38/12, C07D 257/10, C07K 5/12 (86) International application number: PCT/US0019/627 (87) International publication number: WO 0107/042 (01.02.2001 Gazette 2001/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.07.1999 US 145329 P (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)

(72) Inventors: MEINKE, Peter, T. Rahway, NJ 07065-0907 (US) SCHMATZ, Dennis Rahway, NJ 07065-0907 (US) FISHER, Michael, H. Rahway, NJ 07065-0907 (US) RATTRAY, Sandra, J. Rahway, NJ 07065-0907 (US) COLLETTI, Steven, L. Rahway, NJ 07065-0907 (US) WYVRATT, Matthew, J. Rahway, NJ 07065-0907 (US) MYERS, Robert, W. Rahway, NJ 07065-0907 (US) GURNETT, Anne, M. Rahway, NJ 07065-0907 (US) (74) Representative: Thompson, John Dr.  Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)