(19)
(11) EP 1 204 664 A1

(12)

(43) Date of publication:
15.05.2002 Bulletin 2002/20

(21) Application number: 00952317.6

(22) Date of filing: 28.07.2000
(51) International Patent Classification (IPC)7: C07D 491/04, C07D 495/04, C07D 401/06, C07D 451/06, C07D 519/00, C07D 471/04, A61K 31/4353, A61K 31/436, A61K 31/4365, A61K 31/55, A61P 37/00
// (C07D491/04, 313:00), C07D221:00,(C07D495/04, 337:00), C07D221:00,(C07D491/04, 311:00), C07D221:00,(C07D519/00, 491:00), C07D491:00
(86) International application number:
PCT/US0020/775
(87) International publication number:
WO 0109/137 (08.02.2001 Gazette 2001/06)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 28.07.1999 US 362836
29.07.1999 US 363099

(71) Applicants:
  • Millennium Pharmaceuticals, Inc.
    Cambridge,Massachusetts 02139 (US)
  • KYOWA HAKKO KOGYO CO., LTD.
    Chiyoda-ku,Tokyo 100-8185 (JP)

(72) Inventors:
  • LULY, Jay, R.
    Wellesley, MA 02481 (US)
  • NAKASATO, Yoshisuke
    Sunto-gun,Shizuoka 411 (JP)
  • OHSHIMA, Etsuo
    Nagareyama -shi,Chiba 270-0115 (JP)
  • SONE, Hiroki
    Sunto-gun,Shizuoka 411 (JP)
  • KOTERA, Osamu
    Sunto-gun,Shizuoka 411 (JP)
  • HARRIMAN, Geraldine, C., B.
    Charlestown, RI 02813 (US)
  • CARSON, Kenneth, G.
    Needham, MA 02492 (US)

(74) Representative: Keen, Celia Mary 
J.A. Kemp & Co.14 South SquareGray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR