(19)

(11)

EP 1 206 233 A2

(12)

(88) Date of publication A3: 31.01.2002 (43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00942939.0 (22) Date of filing: 20.06.2000

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US0016/847 (87) International publication number: WO 0108/634 (08.02.2001 Gazette 2001/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.08.1999 US 147005 P 09.09.1999 US 152935 P 01.11.1999 US 162979 P 14.03.2000 US 189025 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: RUBEN, Steven, M. Olney, MD 20832 (US) YOUNG, Paul, E. Gaithersburg, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)