(19)

(11)

EP 1 206 449 A1

(12)

(43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00950642.9 (22) Date of filing: 26.07.2000

(51) International Patent Classification (IPC)7: C07D 207/26, C07D 211/76, C07D 223/10, C07D 233/12, C07F 5/02, A61K 31/4015, A61K 31/45, A61K 31/55, A61K 33/22, A61P 31/14 (86) International application number: PCT/US0020/189 (87) International publication number: WO 0107/407 (01.02.2001 Gazette 2001/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.07.1999 US 145631 P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)	(72) Inventors: PRIESTLEY, E., Scott Hockessin, DE 19707 (US) DECICCO, Carl, P. Kennett Square, PA 19348 (US) (74) Representative: Howard, Paul Nicholas et al Carpmaels & Ransford43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)