(19)

(11)

EP 1 206 477 A1

(12)

(43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00950713.8 (22) Date of filing: 26.07.2000

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C12N 9/00, C12N 15/00, C12N 5/00, C12N 1/20 (86) International application number: PCT/US0020/331 (87) International publication number: WO 0109/155 (08.02.2001 Gazette 2001/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.07.1999 US 146699 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventors: MACNEIL, Douglas, J. Rahway, NJ 07065-0907 (US) OCCI, James Rahway, NJ 07065-0907 (US) GEWAIN, Keith, M. Rahway, NJ 07065-0907 (US) (74) Representative: Hiscock, Ian James  European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)