(19)

(11)

EP 1 206 487 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00957528.3 (22) Date of filing: 17.08.2000

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/US0022/609 (87) International publication number: WO 0112/664 (22.02.2001 Gazette 2001/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.08.1999 US 149934 P (71) Applicant: CHIRON CORPORATION Emeryville,California 94608 (US)	(72) Inventors: VIVIEN, Chan Emeryville, CA 94608 (US) ROHAN, Michael Emeryville, CA 94608 (US) WILLIAMS, Lewis, T. Tiburon, CA 94941 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)