(19)

(11)

EP 1 206 491 A1

(12)

(43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00959200.7 (22) Date of filing: 10.08.2000

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 14/715, C12N 5/10, C12N 15/12, C12N 15/63, C12N 15/64 (86) International application number: PCT/US0021/736 (87) International publication number: WO 0112/670 (22.02.2001 Gazette 2001/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.08.1999 US 148682 P 20.09.1999 US 154887 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: RUBEN, Steven, M. Olney, MD 20832 (US) NI, Jian Rockville, MD 20853 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)