(19)

(11)

EP 1 206 541 A1

(12)

(43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00953810.9 (22) Date of filing: 03.08.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 5/10, C12P 21/02, C07K 14/47 (86) International application number: PCT/US0021/130 (87) International publication number: WO 0111/046 (15.02.2001 Gazette 2001/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.08.1999 US 369248 17.03.2000 US 190062 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: RUBEN, Steven, A. Olney, MD 20832 (US) YOUNG, Paul, E. Gaithersburg, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)