(19)

(11)

EP 1 206 545 A1

(12)

(43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00949429.5 (22) Date of filing: 31.07.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/21, C07K 16/12, A61K 39/02, A61K 39/395, A61K 48/00, G01N 33/569 (86) International application number: PCT/EP0007/421 (87) International publication number: WO 0109/338 (08.02.2001 Gazette 2001/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.08.1999 GB 9918279 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE)	(72) Inventor: Thonnard, Joelle,SmithKline Beecham Biol. S.A. 1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)