(19)

(11)

EP 1 206 552 A2

(12)

(88) Date of publication A3: 14.03.2002 (43) Date of publication: 22.05.2002 Bulletin 2002/21 (21) Application number: 00954026.1 (22) Date of filing: 09.08.2000

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 9/64, C12N 1/20, C12N 5/10, C12N 1/15, C07K 16/40, C12N 15/62, C07K 19/00 (86) International application number: PCT/US0022/156 (87) International publication number: WO 0112/788 (22.02.2001 Gazette 2001/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.08.1999 US 376445 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: PRESNELL, Scott, R. Tacoma, WA 98407 (US) TAFT, David W. Seattle, WA 98102 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)