(19)

(11)

EP 1 207 856 A2

(12)

(88) Date of publication A3: 20.09.2001 (43) Date of publication: 29.05.2002 Bulletin 2002/22 (21) Application number: 00956682.9 (22) Date of filing: 31.08.2000

(51) International Patent Classification (IPC)7: A61K 9/16 (86) International application number: PCT/GB0003/328 (87) International publication number: WO 0115/664 (08.03.2001 Gazette 2001/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.08.1999 GB 9920558 (71) Applicants: Bradford Particle Design Limited Bradford,West Yorkshire BD7 1HR (GB) BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)

(72) Inventors: YORK, Peter Ilkley LS29 9PR (GB) WILKINS, Simon Anthony FarsleyLeeds LS28 5BP (GB) STOREY, Richard Anthony CanterburyKent CT4 7TJ (GB) WALKER, Stephen Ernest ShipleyWest Yorkshire BD17 7JX (GB) HARLAND, Ronald, Scott Yardley, PA 19067 (US) (74) Representative: Brewster, Andrea Ruth et al Greaves Brewster24 A Woodborough Road Winscombe, North Somerset BS25 1AD Winscombe, North Somerset BS25 1AD (GB)