(19)

(11)

EP 1 207 863 A2

(12)

(88) Date of publication A3: 28.02.2002 (43) Date of publication: 29.05.2002 Bulletin 2002/22 (21) Application number: 00940669.5 (22) Date of filing: 30.06.2000

(51) International Patent Classification (IPC)7: A61K 31/00 (86) International application number: PCT/GB0002/516 (87) International publication number: WO 0101/970 (11.01.2001 Gazette 2001/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.07.1999 GB 9915414 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)

(72) Inventors: BURBIDGE, Stephen Anthony,Glaxo Wellcome PLC Stevenage, Hertfordshire SG1 2NY (GB) CLARE, Jeffrey John,Glaxo Wellcome PLC Stevenage, Hertfordshire SG1 2NY (GB) COX, Brian,Glaxo Wellcome PLC Stevenage, Hertfordshire SG1 2NY (GB) DUPERE, Joseph,3 East Road Cranfield, Bedfordshire MK43 0TD (GB) HAGAN, Russell Michael,Glaxo Wellcome Inc. Research Triangle Park, NC 27709 (US) XIE, Xinmin Burlingame, Ca 94010 (US) (74) Representative: Hockley, Siân Catherine et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)