(19)

(11)

EP 1 207 887 A2

(12)

(88) Date of publication A3: 23.08.2001 (43) Date of publication: 29.05.2002 Bulletin 2002/22 (21) Application number: 00952812.6 (22) Date of filing: 03.08.2000

(51) International Patent Classification (IPC)7: A61K 31/557, A61P 3/10, A61P 11/00, A61P 37/00 (86) International application number: PCT/CA0000/896 (87) International publication number: WO 0110/422 (15.02.2001 Gazette 2001/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.08.1999 US 147143 P 01.06.2000 US 208304 P (71) Applicant: HSC Research and Development Limited Partnership Toronto,Ontario M5G 1X8 (CA)	(72) Inventor: PACE-ASCIAK, Cecil R. Toronto, Ontario M4T 1R5 (CA) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)