(19)

(11)

EP 1 208 198 A2

(12)

(88) Date of publication A3: 26.07.2001 (43) Date of publication: 29.05.2002 Bulletin 2002/22 (21) Application number: 00955542.6 (22) Date of filing: 15.08.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/475, C07K 16/22, C12Q 1/68, G01N 33/50, A61K 38/18 (86) International application number: PCT/US0022/326 (87) International publication number: WO 0114/415 (01.03.2001 Gazette 2001/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.08.1999 US 149986 P (71) Applicant: CHIRON CORPORATION EmeryvilleCA 94025 (US)	(72) Inventors: KAVANAUGH, W., Michael Emeryville, CA 94608 (US) CEN, Hui Emeryville, CA 94608 (US) LEE, Pauline Emeryville, CA 94608 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)