(19)

(11)

EP 1 210 306 A2

(12)

(88) Date of publication A3: 24.01.2002 (43) Date of publication: 05.06.2002 Bulletin 2002/23 (21) Application number: 00957574.7 (22) Date of filing: 18.08.2000

(51) International Patent Classification (IPC)7: C07B 61/00, C07B 63/00, C07B 35/02, B01D 15/00 (86) International application number: PCT/US0022/752 (87) International publication number: WO 0114/289 (01.03.2001 Gazette 2001/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.08.1999 US 150015 P 20.08.1999 US 150039 P (71) Applicant: NORTH CAROLINA STATE UNIVERSITY Raleigh, NC 27695-7003 (US)

(72) Inventors: DESIMONE, Joseph, M. Chapel Hill, NC 27516 (US) BIRNBAUM, Eva, R. Los Alamos, NM 87544 (US) CARBONELL, Ruben, G. Raleigh, NC 27612 (US) CRETTE, Stephanie Chapel Hill, NC 27514-5721 (US) MCCLAIN, James, B. Carrboro, NC 27010 (US) MCCLESKEY, T, Mark Los Alamos, NM 87544 (US) POWELL, Kimberly R. Chapel Hill, NC 27514 (US) ROMACK, Timothy Durham, NC 27713 (US) TUMAS, William Las Alamos, NM 87544 (US) (74) Representative: Harrison Goddard Foote  Belgrave HallBelgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)