(19)

(11)

EP 1 210 438 A2

(12)

(88) Date of publication A3: 11.10.2001 (43) Date of publication: 05.06.2002 Bulletin 2002/23 (21) Application number: 00948815.6 (22) Date of filing: 20.07.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/29, C12N 9/52, C12N 9/02, A61K 39/00 (86) International application number: PCT/US0019/763 (87) International publication number: WO 0107/625 (01.02.2001 Gazette 2001/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.07.1999 US 358322 (71) Applicant: CORNELL RESEARCH FOUNDATION, INC. Ithaca, NY 14850 (US)	(72) Inventor: CHANG, Yung-fu Ithaca, NY 14850 (US) (74) Representative: Jones, Graham Henry  Graham Jones & Company77 Beaconsfield Road Blackheath, London SE3 7LG Blackheath, London SE3 7LG (GB)